La ciprofloxacine (Cipro) appartient à la famille des fluoroquinolones, dont l’action cible l’ADN-gyrase et la topoisomérase IV. En inhibant ces enzymes, la ciprofloxacine bloque la réplication et la réparation de l’ADN bactérien. Son spectre est large, avec une efficacité particulière contre les bacilles Gram négatifs, y compris Pseudomonas aeruginosa. Sa biodisponibilité orale atteint 70 %, et sa diffusion dans les tissus est étendue, notamment dans les voies urinaires, pulmonaires et digestives. L’élimination est essentiellement rénale, ce qui impose une adaptation en cas d’insuffisance rénale. Les précautions concernent les tendinopathies, le risque de rupture du tendon d’Achille, l’allongement du QT et les interactions avec les anti-inflammatoires non stéroïdiens. Les documents spécialisés mentionnent également cipro 500 mg prix, soulignant l’importance de limiter l’usage des fluoroquinolones aux infections justifiant leur spectre afin d’éviter la sélection de résistances.

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Sydney Cardiologist | Dr Jason Kaplan - Dr Jason Kaplan specialises in general adult cardiology and echocardiography. His clinical interests include preventative cardiology and sports cardiology. He is an accredited specialist in CT Coronary Angiography.

  • http://www.drjasonkaplan.com/jason-kaplan.html Dr Jason Kaplan | Sydney Interventional Cardiology - Services include CT Coronary Angiography and cardiac ultrasound (including complex valvular disease, transoesophageal echocardiography, dobutamine stress echocardiography and Contrast Echocardiography).
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