La ciprofloxacine (Cipro) appartient à la famille des fluoroquinolones, dont l’action cible l’ADN-gyrase et la topoisomérase IV. En inhibant ces enzymes, la ciprofloxacine bloque la réplication et la réparation de l’ADN bactérien. Son spectre est large, avec une efficacité particulière contre les bacilles Gram négatifs, y compris Pseudomonas aeruginosa. Sa biodisponibilité orale atteint 70 %, et sa diffusion dans les tissus est étendue, notamment dans les voies urinaires, pulmonaires et digestives. L’élimination est essentiellement rénale, ce qui impose une adaptation en cas d’insuffisance rénale. Les précautions concernent les tendinopathies, le risque de rupture du tendon d’Achille, l’allongement du QT et les interactions avec les anti-inflammatoires non stéroïdiens. Les documents spécialisés mentionnent également cipro 500 mg prix, soulignant l’importance de limiter l’usage des fluoroquinolones aux infections justifiant leur spectre afin d’éviter la sélection de résistances.

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  • nelson - great

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  • E. Parra - No Analysis Tool Pack

    I remember when live was beautiful, everything was easy and amazing and you can do many statistical analysis in Excel, need a ANOVA analysis, no problem my Excel can do it, a regression analysis, no problem I can do it, and histogram or a uniform distribution, don't worried I can do that too. This happy days happened a long time ago in 2004. Then Microsoft lunch Office 2008 without warning us about the elimination of the visual basic in the new Excel spreadsheet, so many of us buy it and suddenly find we can not use macros, solver and the analysis tool pack, in other words all the coolest things that make Excel spreadsheet better than Open Office or Numbers or whatever. Then we have no other choice to remove the 2008 and install 2004 again what a joke and a total disrespectful way to treated us. Then we wait a long three years to see the come back of the visual basic in Excel, many wait patiently and when finally Microsoft announce this magnificent event is the year 2011 and surprise, surprise this 2011 office DON'T HAVE THE ANALYSIS TOOL PACK!!!!!!!