La ciprofloxacine (Cipro) appartient à la famille des fluoroquinolones, dont l’action cible l’ADN-gyrase et la topoisomérase IV. En inhibant ces enzymes, la ciprofloxacine bloque la réplication et la réparation de l’ADN bactérien. Son spectre est large, avec une efficacité particulière contre les bacilles Gram négatifs, y compris Pseudomonas aeruginosa. Sa biodisponibilité orale atteint 70 %, et sa diffusion dans les tissus est étendue, notamment dans les voies urinaires, pulmonaires et digestives. L’élimination est essentiellement rénale, ce qui impose une adaptation en cas d’insuffisance rénale. Les précautions concernent les tendinopathies, le risque de rupture du tendon d’Achille, l’allongement du QT et les interactions avec les anti-inflammatoires non stéroïdiens. Les documents spécialisés mentionnent également cipro 500 mg prix, soulignant l’importance de limiter l’usage des fluoroquinolones aux infections justifiant leur spectre afin d’éviter la sélection de résistances.

franklab.cpmc.columbia.edu Review:

Frank Lab - Welcome to the Frank Lab. We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

  • http://franklab.cpmc.columbia.edu/franklab/the-team The Team | Frank Lab - The current members of the Frank Lab, including contact information and links to individual profile pages.
  • http://franklab.cpmc.columbia.edu/franklab/research Research | Frank Lab - An intro to the Frank Lab's research. We study the mechanism of translation on the ribosome by using cryo-EM microscopy and single-particle reconstruction.
  • http://franklab.cpmc.columbia.edu/franklab/research/research-activities Research activities | Frank Lab - A more in-depth description of the Frank Lab's research activities including translation, ribosomes, cryo-electron microscopy, and single-particle
  • http://franklab.cpmc.columbia.edu/franklab/research/equipment-methodology Equipment & Methodology | Frank Lab - Descriptions of the Frank Lab's microscopes, other equipment, and methodology. How we prepare our samples, collect the EM data and analyze them.
  • http://franklab.cpmc.columbia.edu/franklab/research/software Software | Frank Lab - Software routinely used by the Frank Lab: including Spider, Xmipp, and Chimera.
  • http://franklab.cpmc.columbia.edu/franklab/publications Publications | Frank Lab - Extensive lists of all of the Frank Lab publications: refereed articles, invited articles, books, and book chapters.
  • http://franklab.cpmc.columbia.edu/franklab/archives/6349 New paper in PNAS | Frank Lab - Frank Lab. We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction. Joachim Frank.

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