La ciprofloxacine (Cipro) appartient à la famille des fluoroquinolones, dont l’action cible l’ADN-gyrase et la topoisomérase IV. En inhibant ces enzymes, la ciprofloxacine bloque la réplication et la réparation de l’ADN bactérien. Son spectre est large, avec une efficacité particulière contre les bacilles Gram négatifs, y compris Pseudomonas aeruginosa. Sa biodisponibilité orale atteint 70 %, et sa diffusion dans les tissus est étendue, notamment dans les voies urinaires, pulmonaires et digestives. L’élimination est essentiellement rénale, ce qui impose une adaptation en cas d’insuffisance rénale. Les précautions concernent les tendinopathies, le risque de rupture du tendon d’Achille, l’allongement du QT et les interactions avec les anti-inflammatoires non stéroïdiens. Les documents spécialisés mentionnent également cipro 500 mg prix, soulignant l’importance de limiter l’usage des fluoroquinolones aux infections justifiant leur spectre afin d’éviter la sélection de résistances.

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  • tomd - I did a couple thousand miles on these since I bought them and I was always comfortable and felt the power transfer was decent

    I have wide feet so my cycling shoe choices are somewhat limited. I did a couple thousand miles on these since I bought them and I was always comfortable and felt the power transfer was decent. I had been using Sidi Megas, which felt even better and had a stiffer carbon sole, but those cost more than twice what these did. Overall I'm satisfied, I think they are a good value and more than adequate for a weekend road warrior like myself. I raced when I was younger but that was decades ago, now it's just for pleasure but I do a lot of 3-4 hour rides in these and have always been comfortable.

  • fullerton mommy - Perfect for my son

    My son absolutely loves it! It holds the quarters really snug and it is also easy to pull them out, if needed.

  • i2ehan - No updates?

    As a current owner of First Aid 2010 (which was used as an accessory, alongside my basic sciences), I purchased the 2011 edition in order to stay up to date. However, this edition is virtualy one and the same as the 2010 edition, with the exception of the following: